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The risk of bleeding in the skull, which increases with age, is most directly related to:

  1. a decrease in neurons

  2. blood vessel dilation

  3. meningeal deterioration

  4. shrinkage of the brain

The correct answer is: a decrease in neurons

An increase in age can cause a decrease in neurons, leading to thinning of the cerebral cortex and weakening of the blood vessels that support it. Thinning of the cerebral cortex can also lead to an increase in blood vessel dilation, but this is more indirect. Meningeal deterioration and shrinkage of the brain are not directly linked to the risk of bleeding in the skull.